Lead the medicinal chemistry activities of one or more small-molecule drug discovery projects at target validation, hit to lead or lead optimization stages.
Work together with core team members across multiple disciplines to design and implement project strategies for the advancement of projects leading to identify high-quality pre-clinical candidates.
Independently design biologically active molecules and conduct SAR studies to meet the project goals; design synthetic routes and lead the internal or external chemistry team in the synthesis and characterization of drug candidates for the projects.
Work with computational chemistry group to develop structure-based target molecules for projects.
Proactively communicate project strategy, critical issues and recommendations to enable appropriate resource decisions.
Provide supervision, scientific mentorship and technical training of the team members.
Maintain excellent communication across internal and external team members.
PhD in chemistry or related discipline.
A minimum of five years of experience in medicinal chemistry required; candidates with demonstrable hands-on small molecule drug discovery and pre-clinical development experience in pharmaceutical/biotech industry highly desired.
Strong track record of individual and team-level contributions to the discovery and pre-clinical development of small molecule clinical candidates supported with high impact publications, oral presentations and patent applications.
Excellent background and expertise in organic chemistry with a high level of synthetic skill including novel route design is essential.
Demonstrated project leadership experience in leading all stages of small molecule drug discovery with the ability to define strategy and critical decision making.
Excellent problem solving and interpersonal skills with the ability to work well with members of the research and management teams in a dynamic and highly collaborative environment.
Experience in leading and collaborating with chemistry teams from CROs is a plus but not required.